PET/CT in Evaluation Bone Marrow Infiltration in Malignant Lymphoma

Bone marrow stroma contains multi-potential non-hematopoietic progenitor cells capable of differentiating into various tissues of mesenchymal origin, including osteoblasts, endothelial cells, reticular cells, fibroblasts and adipocytes. The bone marrow's microvasculature with a single layer endothelium forms sinusoid, which radically distributes around the draining central sinus. The vasculature provides the barrier between the bone marrow compartment as a functional and spatial entity from extra lymphoid organ and the peripheral circulation {2}.